Reaction: DHB is hydroxylated to DHDB by COQ6
- in pathway: Ubiquinol biosynthesis
A flavin-dependent monooxygenase involved in ubiquinone/ubiquinol biosynthesis, COQ6 (Heeringa et al. 2011) catalyses the C5-hydroxylation of 3-decaprenyl-4-hydroxybenzoic acid (DHB) to 3,4-dihydroxy-5-decaprenylbenzoic acid (DHDB). COQ6 is a peripheral membrane protein that localizes to the matrix side of the inner mitochondrial membrane (Gin et al. 2003). This reaction involving COQ6 is inferred from the equivalent reaction in yeast (Ozeir et al. 2011, Gin et al. 2003).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
DHDB [mitochondrial matrix]
H2O [mitochondrial matrix]
DHB [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-2162187
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Reaction input - small molecules:
4-hydroxy-3-all-trans-decaprenylbenzoic acid
dioxygen
hydron
NADPH
Reaction output - small molecules:
NADP(+)
3-decaprenyl-4,5-dihydroxybenzoic acid
water
Reactome.org link: R-HSA-2162187