Reaction: DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase
- in pathway: Ubiquinol biosynthesis
2-methoxy-6-decaprenylphenol (DMPhOH) is enzymatically converted to 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2). It was thought at one time that the flavin-dependent monooxygenase, COQ6, was the enzyme that catalysed this reaction, however, it has been subsequently shown that COQ6 is not essential for this reaction (Ozeir et al. 2011). However, it is still believed that another member of the COQ family catalyses this event. This reaction is inferred from the equivalent reaction in yeast (Gin et al. 2003, Ozeir et al. 2011).
Reaction - small molecule participants:
MDMQ10H2 [mitochondrial matrix]
NADP+ [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
DMPhOH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-2162191
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Reaction input - small molecules:
dioxygen
hydron
NADPH
2-decaprenyl-6-methoxyphenol
Reaction output - small molecules:
2-decaprenyl-6-methoxyhydroquinone
NADP(+)
water
Reactome.org link: R-HSA-2162191