Reaction: PHB and all-E-10PrP2 are combined into DHB by COQ2
- in pathway: Ubiquinol biosynthesis
4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.
Reaction - small molecule participants:
DHB [mitochondrial matrix]
PPi [mitochondrial matrix]
all-E-10PrP2 [mitochondrial matrix]
PHB [mitochondrial matrix]
Reactome.org reaction link: R-HSA-2162192
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Reaction input - small molecules:
all-trans-decaprenyl diphosphate
4-hydroxybenzoic acid
Reaction output - small molecules:
4-hydroxy-3-all-trans-decaprenylbenzoic acid
diphosphate(3-)
Reactome.org link: R-HSA-2162192