Reaction: GUSB tetramer hydrolyses (HA)2
- in pathway: Hyaluronan uptake and degradation
The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from the HA tetrasaccharide (Oshima et al. 1987) resulting in the single sugars glucuronic acid and N-acetylglucosamine. These single sugars can exit the lysosome by an unknown mechanism. L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).
Reaction - small molecule participants:
GlcA [lysosomal lumen]
H2O [lysosomal lumen]
Reactome.org reaction link: R-HSA-2162227
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Reaction input - small molecules:
water
Reaction output - small molecules:
D-glucuronic acid
Reactome.org link: R-HSA-2162227