Reaction: 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane
- in pathway: HDL assembly
In an ATP-dependent reaction, ATP-binding cassette sub-family A member 1 (ABCA1, ATPA1) mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane. Cholesterol associated with cytosolic vesicles is a substrate for this reaction. Under physiologocal conditions, the active form of ABCA1 is predominantly a tetramer associated with apolipoprotein A-I (APOA1) (Denis et al. 2004; Vedhachalam et al., 2007). The number of lipid molecules transported per ATP consumed is not known.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
CHOL [plasma membrane]
H2O [cytosol]
CHOL [transport vesicle membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-216723
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Reaction input - small molecules:
water
cholesterol
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
cholesterol
Reactome.org link: R-HSA-216723