Reaction: Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
- in pathway: HDL assembly
Extracellular apolipoprotein A-I interacts with phospholipid- and cholesterol-rich membrane patches formed through the action of ABCA1, binding these two lipids to form a discoidal (small nascent) HDL particle (HDL 3c - Kontush and Chapman 2006). The apoA-I molecules that accept lipids in this reaction appear to be different from the ones that activate ABCA1 at the plasma membrane (Hassan et al. 2007; Vedhachalam et al. 2007).
Reaction - small molecule participants:
CHOL [plasma membrane]
PL [plasma membrane]
Reactome.org reaction link: R-HSA-216756
======
Reaction input - small molecules:
cholesterol
phospholipid
Reaction output - small molecules:
Reactome.org link: R-HSA-216756