Reaction: FMO2:FAD:Mg2+ S-oxidises MTZ
- in pathway: FMO oxidises nucleophiles
Methimazole is a drug used to treat hyperthyroidism, a condition arising when the thyroid gland is producing too much thyroid hormone. FMO2 is able to the S-oxidized form of methimazole.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
MTZ-SOX [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
MTZ [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-217258
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Reaction input - small molecules:
dioxygen
hydron
NADPH
methimazole
Reaction output - small molecules:
water
NADP(+)
methimazole S-oxide
Reactome.org link: R-HSA-217258