Reaction: MTMR4 dephosphorylates SMAD2/3
- in pathway: Downregulation of TGF-beta receptor signaling
MTMR4 protein phosphatase dephosphorylates SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers and inhibiting transmission of TGF-beta signal to the nucleus (Yu et al. 2010).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-2187401
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-2187401