Reaction: CDK8 phosphorylates NICD1 PEST domain mutants
- in pathway: Constitutive Signaling by NOTCH1 PEST Domain Mutants
While CDK8 can probably phosphorylate the TAD domain of NICD1 PEST domain mutants, it cannot phosphorylate the PEST domain of these mutants as it is partially or completely truncated (Fryer et al. 2004).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-2220971
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-2220971