Reaction: RAB8A,10,13,14 exchange GDP for GTP
- in pathway: Translocation of SLC2A4 (GLUT4) to the plasma membrane
RAB8A/10/13/14 release GDP and bind GTP to yield the active complex. Guanine nucleotide exchange factors (GEFs) stimulate the reaction. GTPase-activating proteins (GAPs) oppose the reaction by stimulating the intrinsic GTPase activity of the RAB proteins.
Reaction - small molecule participants:
GDP [cytoplasmic vesicle membrane]
GTP [cytoplasmic vesicle membrane]
Reactome.org reaction link: R-HSA-2255343
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Reaction input - small molecules:
GTP
Reaction output - small molecules:
GDP
Reactome.org link: R-HSA-2255343