Reaction: PGG2 is reduced to PGH2 by PTGS2
- in pathway: Nicotinamide salvaging
Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
PGH2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
e- [endoplasmic reticulum lumen]
PGG2 [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
PGH2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
e- [endoplasmic reticulum lumen]
PGG2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2309773
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Reaction input - small molecules:
hydron
electron
prostaglandin G2
hydron
electron
prostaglandin G2
Reaction output - small molecules:
water
prostaglandin H2
water
prostaglandin H2
Reactome.org link: R-HSA-2309773