Reaction: Arachidonic acid is oxidised to PGG2 by PTGS2
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Prostaglandin G/H synthase PTGS2 exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The cyclooxygenase function catalyzes the initial conversion of arachidonic acid to an intermediate, prostaglandin G2 (PGG2) (Hamberg et al. 1974, Nugteren 1973).
Reaction - small molecule participants:
PGG2 [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
AA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2309787
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Reaction input - small molecules:
dioxygen
arachidonate
Reaction output - small molecules:
prostaglandin G2
Reactome.org link: R-HSA-2309787