Reaction: ASA- acetylates PTGS2
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
The ionized form of aspirin, acetylsalicylate (ASA-) reacts spontaneously with one subunit of PTGS2 dimer (Dong et al. 2011) to acetylate serine residue 516 (Lecomte et al. 1994). The modified enzyme is no longer capable of catalyzing the conversion of arachidonic acid to PGH2, but acquires the ability to convert it to 15R-HETE.
Reaction - small molecule participants:
ST [cytosol]
ASA- [cytosol]
Reactome.org reaction link: R-HSA-2314686
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Reaction input - small molecules:
acetylsalicylate
Reaction output - small molecules:
salicylate
Reactome.org link: R-HSA-2314686