Reaction: PIP3 recruits PDPK1 to the membrane
- in pathway: PIP3 activates AKT signaling
PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-2316429
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reaction output - small molecules:
Reactome.org link: R-HSA-2316429