Reaction: Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP
- in pathway: Phosphate bond hydrolysis by NUDT proteins
Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. Each NUDT5 subunit is associated with three magnesium ions (Zha et al. 2006, 2008). NUDT5 also catalyzes the hydrolysis of 8-oxo-dGTP but with a strongly alkaline pH optimum (Ito et al. 2011) so the physiological relevance of this reaction is unclear and it is not annotated here.
Reaction - small molecule participants:
R5P [cytosol]
AMP [cytosol]
H2O [cytosol]
ADP-D-ribose [cytosol]
Reactome.org reaction link: R-HSA-2393939
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Reaction input - small molecules:
water
ADP-D-ribose(2-)
Reaction output - small molecules:
D-ribofuranose 5-phosphate(2-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-2393939