Reaction: Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP
- in pathway: Phosphate bond hydrolysis by NUDT proteins
Mitochondrial NUDT9 (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. The active enzyme is the longer of two isoforms generated by alternative splicing and is a monomer complexed with two magnesium ions (Perraud et al. 2003; Shen et al. 2003).
Reaction - small molecule participants:
R5P [mitochondrial matrix]
AMP [mitochondrial matrix]
ADP-Rib [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-2393954
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Reaction input - small molecules:
ADP-D-ribose(2-)
water
Reaction output - small molecules:
D-ribofuranose 5-phosphate(2-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-2393954