Reaction: NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP
- in pathway: Phosphate bond hydrolysis by NUDT proteins
NUDT15 (MTH2) catalyzes the reaction of 8-oxo-dGTP and water to form 8-oxo-dGMP and PPi (pyrophosphate). Cai et al. (2003) first identified this activity in studies of the homologous mouse protein; the activity of the human NUDT15 protein has since been confirmed experimentally (Takagi et al. 2012).
Reaction - small molecule participants:
PPi [cytosol]
H+ [cytosol]
8-oxo-dGMP(2-) [cytosol]
H2O [cytosol]
8-oxo-dGTP(4-) [cytosol]
Reactome.org reaction link: R-HSA-2395869
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Reaction input - small molecules:
water
8-oxo-dGTP(4-)
Reaction output - small molecules:
diphosphate(3-)
hydron
8-oxo-dGMP(2-)
Reactome.org link: R-HSA-2395869