Reaction: NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP
- in pathway: Phosphate bond hydrolysis by NUDT proteins
NUDT15 (MTH2) catalyzes the reaction of 8-oxo-dGDP and water to form 8-oxo-dGMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT15 has not been established but is assumed to be cytosolic like NUDT1.
Reaction - small molecule participants:
Pi [cytosol]
H+ [cytosol]
8-oxo-dGMP(2-) [cytosol]
H2O [cytosol]
8-oxo-dGDP(3-) [cytosol]
Reactome.org reaction link: R-HSA-2395876
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Reaction input - small molecules:
water
8-oxo-dGDP(3-)
Reaction output - small molecules:
hydrogenphosphate
hydron
8-oxo-dGMP(2-)
Reactome.org link: R-HSA-2395876