Reaction: AKT1 E17K mutant phosphorylates BAD
- in pathway: Constitutive Signaling by AKT1 E17K in Cancer
AKT1 E17K gain-of-function mutant phosphorylates BAD (Guo et al. 2010). AKT-mediated BAD phosphorylation inactivates BAD, thereby preventing BAD-mediated apoptosis (Del Peso et al. 1997).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2399941
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-2399941