Reaction: A REH hydrolses atREs to atROL and FAs
- in pathway: Retinoid metabolism and transport
Retinyl esters (REs) are stored in lipid droplets (LDs) in hepatic stellate cells (HSCs) until there is a demand for retinoid by the body. Mobilization of atREs stores require lipases with retinyl ester hydrolase (REH) activity. At present, the identity of the REH mediating atRE mobilization is unknown (see reviews Shirakami et al. 2012, Schreiber et al. 2012). In studies performed with rat livers, Mello et al. found that the carboxylesterases ES4 and ES10 possessed REH activity and were localised to HSCs (Mello et al. 2008) but it's not confirmed that these are the actual REHs involved in retinoid mobilization. The human orthologue to these rat enzymes is presently unknown.
Reaction - small molecule participants:
atROL [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-2404133
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Reaction input - small molecules:
water
Reaction output - small molecules:
all-trans-retinol
Reactome.org link: R-HSA-2404133