Reaction: IGF1,2:IGF1R autophosphorylates
CILP1 (CILP-1) inhibits ligand-induced autophosphorylation of IGF1R, the IGF-1 receptor (Johnson et al. 2003). CILP1 is expressed in chondrocytes and cultured knee meniscal cartilage cells where it blocks the ability of IGF1 to reduce extracellular pyrophosphate. Expression of CILP1 is commonly enhanced in aging and osteoarthritic cartilage.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2404199
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-2404199