Reaction: Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK
- in pathway: Selenocysteine synthesis
L-seryl-tRNA(Sec) kinase (PSTK) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+. PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer. This reaction involving PSTK is inferred from the equivalent reaction in mouse.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2408507
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-2408507