Reaction: H2SeO4 is converted to APSe by PAPSS1,2
- in pathway: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in transforming adenosine triphosphate (ATP) and selenic acid (H2SeO4) into adenylylselenate (APSe) and diphosphate via its ATP sulphurylase domain. This reaction is inferred from the event in rat (Yu et al. 1989).
Reaction - small molecule participants:
PPi [cytosol]
APSe [cytosol]
H2SeO4 [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2408525
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Reaction input - small molecules:
selenic acid
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenylyl selenate
Reactome.org link: R-HSA-2408525