Reaction: Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH
- in pathway: Metabolism of ingested SeMet, Sec, MeSec into H2Se
Excess selenomethionine (SeMet) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and 2-oxobutanoic acid. This reaction is inferred from the event in mouse involving the protein cystathionine gamma-lyase (Cth) (Okuno et al. 2001, Okuno et al. 2005, Okuno et al. 2006).
Reaction - small molecule participants:
NH3 [cytosol]
2OBUTA [cytosol]
MeSeH [cytosol]
H2O [cytosol]
SeMet [cytosol]
Reactome.org reaction link: R-HSA-2408537
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Reaction input - small molecules:
water
L-selenomethionine
Reaction output - small molecules:
ammonia
2-oxobutanoic acid
methylselenol
Reactome.org link: R-HSA-2408537