Reaction: MeSec is hydrolysed to MeSeH by PXLP-K212-CTH
- in pathway: Metabolism of ingested SeMet, Sec, MeSec into H2Se
Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) (Pinto et al. 2011, Suzuki et al. 2007).
Reaction - small molecule participants:
NH3 [cytosol]
pyruvic acid [cytosol]
MeSeH [cytosol]
MeSec [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-2408539
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Reaction input - small molecules:
Se-methyl-L-selenocysteine
water
Reaction output - small molecules:
ammonia
pyruvate
methylselenol
Reactome.org link: R-HSA-2408539