Reaction: APSe is phosphorylated to PAPSe by PAPSS1,2
- in pathway: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in phosphorylating adenylylselenate (APSe) into 3'-phosphoadenylyl selenate (PAPSe) via its APS kinase domain. This reaction is inferred from the event in Penicillium chrysogenum involving APS kinase (Kaps) (Yu et al. 1989).
Reaction - small molecule participants:
PAPSe [cytosol]
ADP [cytosol]
APSe [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2408540
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Reaction input - small molecules:
adenylyl selenate
ATP(4-)
Reaction output - small molecules:
3'-phosphoadenylyl selenate
ADP(3-)
Reactome.org link: R-HSA-2408540