Reaction: SeCysta is hydrolysed to Sec by PXLP-K212-CTH
- in pathway: Metabolism of ingested SeMet, Sec, MeSec into H2Se
Cystathionine gamma-lyase (CTH) homotetramer is involved in the hydrolysis of selenocystathionine (SeCysta) into selenocysteine (Sec), ammonia and 2-oxobutanoic acid by an alpha,gamma-elimination reaction. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) homotetramer (Esaki et al. 1981).
Reaction - small molecule participants:
NH3 [cytosol]
2OBUTA [cytosol]
Sec [cytosol]
H2O [cytosol]
SeCysta [cytosol]
Reactome.org reaction link: R-HSA-2408543
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Reaction input - small molecules:
water
L-selenocystathionine
Reaction output - small molecules:
ammonia
2-oxobutanoic acid
L-selenocysteine
Reactome.org link: R-HSA-2408543