Reaction: AdoSeMet is converted to AdeSeHCys by MetTrans(1)
- in pathway: Metabolism of ingested SeMet, Sec, MeSec into H2Se
A set of methyltransferases (MetTrans(1)) consisting of the proteins histamine-N-methyltransferase (HNMT), glycine-N-methyltransferase (GNMT), and nicotinamide-N-methyltransferase (NNMT) remove a methyl group from adenosylselenomethionine (AdoSeMet) to leave adenosylselenohomocysteine (AdeSeHCys). This reaction is inferred from the event in rat involving the set of methyltransferases (MetTrans(2)) consisting of the proteins histamine-N-methyltransferase (Hnmt), glycine-N-methyltransferase (Gnmt), and nicotinamide-N-methyltransferase (Nnmt) (Kajander et al. 1991).
Reaction - small molecule participants:
AdeSeHCys [cytosol]
AdoSeMet [cytosol]
Reactome.org reaction link: R-HSA-2408544
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Reaction input - small molecules:
L-adenosylselenomethionine
Reaction output - small molecules:
L-adenosylselenohomocysteine
Reactome.org link: R-HSA-2408544