Reaction: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex
- in pathway: Selenoamino acid metabolism
As a first step in the incorporation of selenomethionine into proteins, tRNA(Met) is converted into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)) by methionine-tRNA ligase (MARS) component of a multisynthetase complex comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. It is involved in the selenomethionylation of tRNA(Met) into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)). This reaction is inferred from the event in mung bean (Burnell 1981) and in wheat germ (Eustice et al. 1981).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
SeMet [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2408546
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Reaction input - small molecules:
L-selenomethionine
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-2408546