Reaction: SeMet is converted to AdoSeMet by MAT
- in pathway: Metabolism of ingested SeMet, Sec, MeSec into H2Se
Methionine adenosyltransferases (MAT multimers) consisting of a S-adenosylmethionine synthase isoform type-1 (MAT1A) homodimer and a MAT1A: S-adenosylmethionine synthase isoform type-2 (MAT2A) heterodimer are responsible for the conversion of selenomethionine (SeMet) and ATP into Se-adenosylselenomethionine (AdoSeMet), orthophosphate (Pi), and diphosphate (PPi) (Kajander et al. 1990).
Reaction - small molecule participants:
PPi [cytosol]
Pi [cytosol]
AdoSeMet [cytosol]
H2O [cytosol]
SeMet [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2408551
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Reaction input - small molecules:
water
L-selenomethionine
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
hydrogenphosphate
L-adenosylselenomethionine
Reactome.org link: R-HSA-2408551