Reaction: SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+
- in pathway: ECM proteoglycans
Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, binds Collagen type I, hydroxyapatite and Ca2+, suggesting a role in the mineralization of bone and cartilage (Termine et al. 1981). It is expressed by osteoblasts, odontoblasts, and many other cell types (Romanowski et al. 1990, Mundlos et al. 1992, Papagerakis et al. 2002). SPARC expression has been used to follow the progression of osteoblast cytodifferentiation.
Reaction - small molecule participants:
Hydroxylapatite [extracellular region]
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-2424243
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Reaction input - small molecules:
hydroxylapatite
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-2424243