Reaction: STRA6 transports atROL from extracellular region to cytosol
- in pathway: The canonical retinoid cycle in rods (twilight vision)
Stimulated by retinoic acid gene 6 protein homologue (STRA6) acts as a high-affinity cell-surface receptor for the TTR:RBP4:atROL complex (Berry et al. 2012). Once bound, STRA6 removes atROL and transports it into cells expressing STRA6 receptors, including eye (Kawaguchi et al. 2007). Defects in STRA6 cause microphthalmia syndromic type 9 (MCOPS9, Matthew-Wood syndrome or Spear syndrome; MIM:601186) (Chassaing et al. 2009). The uptake of atROL is driven by the conversion of atROL to retinyl ester (RE) by LRAT (Kawaguchi et al. 2011).
Reaction - small molecule participants:
atROL [cytosol]
Reactome.org reaction link: R-HSA-2453863
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Reaction input - small molecules:
Reaction output - small molecules:
all-trans-retinol
Reactome.org link: R-HSA-2453863