Reaction: RDH5 oxidises 11cROL to 11cRAL
- in pathway: The canonical retinoid cycle in rods (twilight vision)
Another member of the short-chain dehydrogenases/reductases (SDR) family, RDH5, can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells using NAD+ as cofactor (Simon et al. 1996, Gonzalez-Fernandez et al. 1999). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.
Reaction - small molecule participants:
H+ [cytosol]
NADH [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-2454081
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
hydron
NADH(2-)
Reactome.org link: R-HSA-2454081