Reaction: NRPE dissociates to atRAL and PE
- in pathway: The canonical retinoid cycle in rods (twilight vision)
Once NRPE is "flipped" to the cytoplasmic side of disc membranes by the ABC transporter ABCA4, it can dissociate to all-trans-retinal (atRAL) and phosphatidylethanolamine (PE). atRAL is thus released to re-enter the retinoid cycle to reform the visual chromophore 11-cis-retinal (11cRAL) (Tsybovsky et al. 2010).
Reaction - small molecule participants:
atRAL [cytosol]
PE [photoreceptor disc membrane]
NRPE [cytosol]
Reactome.org reaction link: R-HSA-2466718
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Reaction input - small molecules:
N-retinylidenephosphatidylethanolamine
Reaction output - small molecules:
all-trans-retinal
phosphatidylethanolamine zwitterion
Reactome.org link: R-HSA-2466718