Reaction: NRPE condenses with atRAL to form A2PE
- in pathway: Biosynthesis of A2E, implicated in retinal degradation
A phosphatidyl-pyridinium bisretinoid compound, A2PE, is formed through condensation of N-retinylidene-PE (NRPE) and a second all-trans-retinol (atRAL) molecule (Parish et al. 1998, Mata et al. 2000). This most likely happens when atRAL is abundant.
Reaction - small molecule participants:
H2O [cytosol]
A2PE [photoreceptor outer segment membrane]
NRPE [photoreceptor outer segment membrane]
atRAL [photoreceptor disc membrane]
Reactome.org reaction link: R-HSA-2466764
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Reaction input - small molecules:
N-retinylidenephosphatidylethanolamine
all-trans-retinal
Reaction output - small molecules:
water
N-retinylidene-N-retinylphosphatidylethanolamine
Reactome.org link: R-HSA-2466764