Reaction: A2E translocates to RPE cells
- in pathway: Biosynthesis of A2E, implicated in retinal degradation
Once photoreceptor outer segments are phagocytosed, inclusive of A2E, they are delivered to retinal pigment epithelial (RPE) cells for disposal. However, A2E has been shown to be resistant to any sort of degradative enzyme thus accumulates in the RPE. The relationship between lipofuscin accumulation and retinal degeneration is illustrated by Stargardt disease type 1 (STGD1, MIM:248200) (Allikmets et al. 1997).
Reaction - small molecule participants:
A2E [cytosol]
A2E [phagolysosome]
Reactome.org reaction link: R-HSA-2467738
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Reaction input - small molecules:
N-retinylidene-N-retinylethanolamine
Reaction output - small molecules:
N-retinylidene-N-retinylethanolamine
Reactome.org link: R-HSA-2467738