Reaction: A2E is phagocytosed
- in pathway: Biosynthesis of A2E, implicated in retinal degradation
Early experiments in frog and other species determined that the outer segments of photoreceptors are renewed by phagocytosis and transfer to retinal pigment eplithelial (RPE) cells for processing. A2E, formed in disc membranes of outer segments, is taken along with the phagolysosome (Young 1967, Young & Bok 1969, Katz et al. 1986). Here, for simplicity, only A2E is shown in the phagolysosome.
Reaction - small molecule participants:
A2E [phagolysosome]
A2E [photoreceptor outer segment membrane]
Reactome.org reaction link: R-HSA-2467761
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Reaction input - small molecules:
N-retinylidene-N-retinylethanolamine
Reaction output - small molecules:
N-retinylidene-N-retinylethanolamine
Reactome.org link: R-HSA-2467761