Reaction: NUDT16 hydrolyses IDP to IMP
- in pathway: Phosphate bond hydrolysis by NUDT proteins
NUDT16 dimer catalyzes the reaction of IDP and water to form IMP and Pi (orthophosphate). Mg++ is required for enzymatic activity. The protein is mostly located in the nucleus and concentrated in the nucleolus, where it can also mediate the decapping of U8 small nucleolar RNA (Iyama et al. 2010; Peculis et al. 2007).
Reaction - small molecule participants:
Pi [nucleoplasm]
IMP [nucleoplasm]
H+ [nucleoplasm]
H2O [nucleoplasm]
IDP [nucleoplasm]
Reactome.org reaction link: R-HSA-2509816
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Reaction input - small molecules:
water
IDP(3-)
Reaction output - small molecules:
hydrogenphosphate
IMP(2-)
hydron
Reactome.org link: R-HSA-2509816