Reaction: ITPA hydrolyses ITP to IMP
- in pathway: Purine catabolism
Cytosolic ITPA dimer catalyzes the reaction of ITP and water to form IMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of ITP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).
Reaction - small molecule participants:
PPi [cytosol]
H+ [cytosol]
IMP [cytosol]
H2O [cytosol]
ITP [cytosol]
Reactome.org reaction link: R-HSA-2509827
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Reaction input - small molecules:
water
ITP(4-)
Reaction output - small molecules:
diphosphate(3-)
hydron
IMP(2-)
Reactome.org link: R-HSA-2509827