Reaction: ITPA hydrolyses ITP to IMP

- in pathway: Purine catabolism
Cytosolic ITPA dimer catalyzes the reaction of ITP and water to form IMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of ITP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010).
Reaction - small molecule participants:
PPi [cytosol]
H+ [cytosol]
IMP [cytosol]
H2O [cytosol]
ITP [cytosol]
Reactome.org reaction link: R-HSA-2509827

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Reaction input - small molecules:
water
ChEBI:15377
ITP(4-)
ChEBI:61402
Reaction output - small molecules:
diphosphate(3-)
ChEBI:33019
hydron
ChEBI:15378
IMP(2-)
ChEBI:58053
Reactome.org link: R-HSA-2509827