Reaction: ITPA hydrolyses dITP to dIMP
- in pathway: Purine catabolism
Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).
Reaction - small molecule participants:
dIMP [cytosol]
PPi [cytosol]
H+ [cytosol]
dITP [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-2509838
======
Reaction input - small molecules:
dITP(4-)
water
Reaction output - small molecules:
2'-deoxyinosine 5'-phosphate(2-)
diphosphate(3-)
hydron
Reactome.org link: R-HSA-2509838