Reaction: NMT1/2 transfer MYS to GNAT1
After removal of the N-terminal methionine (Met) residue, the enzymes glycylpeptide N-tetradecanoyltransferase 1 and 2 (NMT1 and 2) mediate the transfer of the myristoyl (MYS) group from myristoyl-CoA to the now N-terminal glycine (Gly) residue of transducin's alpha subunit (GNAT1) (Glover et al. 1997, Giang & Cravatt 1998). Myristoylation is thought to aid enzyme function and localization. Evidence from chicken experiments suggest non-myristoylated proteins do not bind to membranes (Kamps et al. 1986).
Reaction - small molecule participants:
CoA-SH [cytosol]
MYS-CoA [cytosol]
Reactome.org reaction link: R-HSA-2534087
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Reaction input - small molecules:
myristoyl-CoA
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-2534087