Reaction: METAP1/2 demethylates GNAT1
All eukaryotic proteins synthesized in the cytosol are initiated by methionine (Met). For the maturation of many proteins, the removal of N-terminal Met is essential and is mediated by methionine-aminopeptidases (METAPs). In human, there are two forms, METAP1 and 2 (Arfin et al. 1995). These enzymes utilise 2 cobalt ions (Co2+) as cofactors (Addlagatta et al. 2005, Hu et al. 2006, Marino et al. 2007).
Reaction - small molecule participants:
L-Met [cytosol]
Reactome.org reaction link: R-HSA-2534096
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Reaction input - small molecules:
Reaction output - small molecules:
L-methionine zwitterion
Reactome.org link: R-HSA-2534096