Reaction: Hv1 Mediated H+ Permeability
- in pathway: Sperm Motility And Taxes
Intracellular alkalinization is essential for the initiation of motility, capacitation, hyperactivation, and the acrosome reaction. Hv1 mediates the voltage-dependent proton permeability of excitable membranes. Hv1 is abundantly expressed in human sperm cells within the principal piece of the sperm flagellum, making it ideally positioned to activate pH-dependent proteins of the axoneme and thus to control sperm motility.
Reaction - small molecule participants:
H+ [extracellular region]
H+ [cytoplasm]
Reactome.org reaction link: R-HSA-2534378
======
Reaction input - small molecules:
hydron
Reaction output - small molecules:
hydron
Reactome.org link: R-HSA-2534378