Reaction: Collagen type IV sulfilimine cross-linking by peroxidasin
- in pathway: Crosslinking of collagen fibrils
A recently discovered sulfilimine (S=N) bond between a methionine sulfur and hydroxylysine nitrogen reinforces the collagen IV network (Vanacore et al. 2005, 2009). Peroxidasin, an enzyme found in basement membranes, indirectly catalyzes formation of the sulfilimine bond by producing the reactive intermediates hypobromous acid from peroxide and free Br- (Bhave 2012, MacCall et al. 2014).
Reaction - small molecule participants:
H2O2 [extracellular region]
Reactome.org reaction link: R-HSA-2559639
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Reaction input - small molecules:
hydrogen peroxide
Reaction output - small molecules:
Reactome.org link: R-HSA-2559639