Reaction: JAK2 Autophosphorylates in Response to Leptin
- in pathway: Signaling by Leptin
As inferred from mouse, binding of Leptin (LEP) to the Leptin receptor (LEPR) causes a conformational change in LEPR that activates autophosphorylation of JAK2 at multiple tyrosine residues. Phosphorylated JAK2 has much higher kinase activity than unphosphorylated JAK2.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-2586555
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-2586555