Reaction: at-retinyl is hydrolysed from p-MII:SAG to release atRAL
Eventually the Schiff base linkage between the all-trans-retinyl (at-retinyl) group and opsin is hydrolyzed, releasing all-trans-retinal (atRAL). atRAL repositions to an "exit" site within opsin and is reduced to all-trans-retinol (atROL) by retinol dehydrogenases RDH8 and RDH12 using NADPH as cofactor (see section on rod retinoid cycle), whereupon it exits the rod (Baumann & Bender 1973).
Reaction - small molecule participants:
atRAL [photoreceptor disc membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-2632521
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Reaction input - small molecules:
water
Reaction output - small molecules:
all-trans-retinal
Reactome.org link: R-HSA-2632521