Reaction: Serum albumin binds 2-lysophosphatidylcholine
- in pathway: HDL remodeling
Serum albumin binds 2-lysophosphatidylcholine (lysolecithin) to form a complex. Two molecules of lipid bind strongly to a molecule of albumin; an additional five molecules bind more weakly (Nakagawa and Nishida 1973). The fate of the complex in vivo is unclear. In vitro 2-lysophosphatidylcholine can be esterified with fatty acid to generate phosphatidylcholine. Such a process could replenish the phosphatidylcholine consumed by cholesterol esterification in HDL particles, but the extent to which it occurs in vivo is unclear (Nakagawa and Nishida 1973; Switzer and Eder 1965).
Reaction - small molecule participants:
1-acyl LPC [extracellular region]
Reactome.org reaction link: R-HSA-264679
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Reaction input - small molecules:
1-O-acyl-sn-glycero-3-phosphocholine(1+)
Reaction output - small molecules:
Reactome.org link: R-HSA-264679