Reaction: Arachidonic acid is oxidised to 5S-HpETE by ALOX5
- in pathway: Synthesis of 5-eicosatetraenoic acids
Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid in a two-step process. First, arachidonic acid AA is oxidized to form 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).
Reaction - small molecule participants:
5S-HpETE [cytosol]
O2 [cytosol]
AA [cytosol]
5S-HpETE [cytosol]
O2 [cytosol]
AA [cytosol]
Reactome.org reaction link: R-HSA-265296
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Reaction input - small molecules:
dioxygen
arachidonate
dioxygen
arachidonate
Reaction output - small molecules:
5(S)-HPETE
5(S)-HPETE
Reactome.org link: R-HSA-265296