Reaction: LTD4 is converted to LTE4 by DPEP1/2
- in pathway: LTC4-CYSLTR mediated IL4 production
Another outer surface membrane-bound, homodimeric enzyme, dipeptidase, existing in two forms DPEP1 (Adachi et al. 1989) and DPEP2 (Lee et al. 1983, Raulf et al. 1987), further hydrolyses leukotriene D4 (LTD4) to leukotriene E4 (LTE4), cleaving a glycine residue in the process.
Reaction - small molecule participants:
Gly [extracellular region]
LTE4 [extracellular region]
LTD4 [extracellular region]
H2O [extracellular region]
Gly [extracellular region]
LTE4 [extracellular region]
LTD4 [extracellular region]
H2O [extracellular region]
Reactome.org reaction link: R-HSA-266012
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Reaction input - small molecules:
leukotriene D4
water
leukotriene D4
water
Reaction output - small molecules:
glycine zwitterion
leukotriene E4
glycine zwitterion
leukotriene E4
Reactome.org link: R-HSA-266012