Reaction: GGT1, 5 dimers hydrolyse LTC4 to LTD4
- in pathway: LTC4-CYSLTR mediated IL4 production
The reversible conversion of leukotriene C4 (LTC4) to leukotriene D4 (LTD4) is catalysed by gamma-glutamyl transferases 1 (GGT1) and 5 (GGT5). GGTs are present on the outer surface of plasma membranes and are a heterodimer of a heavy and a light chain. Its action involves the hydrolysis of the gamma-glutamyl peptide bond of glutathione and glutathione conjugates, releasing glutamate. In this example, LTC4 is a glutathione conjugate that is hydrolysed to LTD4 (Anderson et al. 1982, Wickham et al. 2011).
Reaction - small molecule participants:
LTD4 [extracellular region]
L-Glu [extracellular region]
H2O [extracellular region]
LTC4 [extracellular region]
LTD4 [extracellular region]
L-Glu [extracellular region]
H2O [extracellular region]
LTC4 [extracellular region]
Reactome.org reaction link: R-HSA-266046
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Reaction input - small molecules:
water
leukotriene C4
water
leukotriene C4
Reaction output - small molecules:
leukotriene D4
L-glutamate(1-)
leukotriene D4
L-glutamate(1-)
Reactome.org link: R-HSA-266046